Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents

被引：174

作者：

Banday, Abid H. ^{[1
,2
]}

Mir, Bilal P. ^{[1
]}

Lone, Imtiyaz H. ^{[1
]}

Suri, K. A. ^{[2
]}

Kumar, H. M. Sampath ^{[2
]}

机构：

[1] Islamia Coll Sci & Commerce, Dept Chem, Srinagar 190009, Jammu & Kashmir, India

[2] Indian Inst Integrat Med, Synthet Chem Div, Jammu 180001, India

来源：

STEROIDS | 2010年 / 75卷 / 12期

关键词：

Pyrazoline; Pregnenolone; Benzylidines; Dipolar cycloaddition; HETEROCYCLIC-COMPOUNDS; ANTIPARKINSONIAN AGENTS; ANTIMICROBIAL AGENTS; BIOLOGICAL-ACTIVITY; DERIVATIVES; PYRIDINE; ANTICONVULSANT; SYNTHON;

D O I：

10.1016/j.steroids.2010.02.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds 4b, 4c, 4e, 4f, 4h and 4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：805 / 809

页数：5

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