Synthesis of new potential bis-intercalators based on chiral pyridine-2,6-dicarboxamides

被引：53

作者：

Amr, AE

Abd El-Salam, OI

Attia, AE

Stibor, I ^{[1
]}

机构：

[1] Prague Inst Chem Technol, Dept Organ Chem, CR-16628 Prague 6, Czech Republic

[2] Natl Res Ctr, Dept Organ Chem, Cairo 12622, Egypt

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1999年 / 64卷 / 02期

关键词：

DNA intercalation; chiral intercalators; pyridine-2,6-dicarboxamides; amino acids; naphthalimides; antimicrobial activity;

D O I：

10.1135/cccc19990288

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Potential bis-intercalating compounds N,N-dibenzylidene-N-2,N-2'-(pyridine-2,6-dicarbonyl)- di(aminoacidhydrazides) 4a-4i, N,N'-substituted pyridine-2,6-bis(carbohydrazides) 5a-5d and N,N'-substituted (NN2)-N-2'-bis(pyridine-2,6-dicarbonyl)di(aminoacidhydrazides) 6a-6g, both racemic and optically active, can be easily synthesized from pyridine-2,6-bis(carbohydrazide), natural amino acids and aromatic aldehydes or anhydrides of aromatic ortho-dicarboxylic acids.

引用

收藏

页码：288 / 298

页数：11

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