In vitro activity of daptomycin against methicillin- and multi-resistant Staphylococcus haemolyticus invasive isolates carrying different mec complexes

被引：13

作者：

Campanile, Floriana ^{[1
]}

Bongiorno, Dafne ^{[1
]}

Borbone, Sonia ^{[1
]}

Falcone, Marco ^{[2
]}

Giannella, Maddalena ^{[2
]}

Venditti, Mario ^{[2
]}

Stefani, Stefania ^{[1
]}

机构：

[1] Univ Catania, Dept Microbiol, I-95124 Catania, Italy

[2] Univ Roma La Sapienza, Dept Clin Med, Policlin Umberto I, I-00185 Rome, Italy

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 61卷 / 02期

关键词：

MRSH invasive isolates; daptomycin;

D O I：

10.1016/j.diagmicrobio.2008.01.019

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

Fifty methicillin and multi-resistant Staphylococcus haemolyticus (MRSH) strains, were tested against daptomycin and comparators. Daptomycin showed an overall MIC(90) value of 1 mg/L, similar to that of quinopristin/dalfopristin and lower than the values for vancomycin (2 mg/L), linezolid (2 mg/L) and teicoplanin (32 mg/L). Eighteen strains showed heteroresistant subpopulations with teicoplanin, whereas two strains were also heteroresistant to vancomycin and these sub-populations retained susceptibility to daptomycin. Our results show the good in vitro activity of daptomycin in MRSH strains possessing a multi-resistant phenotype. Clinical data on daptomycin efficacy are necessary to confirm our in vitro findings. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：227 / 231

页数：5

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