Potassium channels, memory T cells, and multiple sclerosis

被引：93

作者：

Beeton, C ^{[1
]}

Chandy, KG ^{[1
]}

机构：

[1] Univ Calif Irvine, Sch Med, Dept Physiol & Biophys, Irvine, CA 92697 USA

来源：

NEUROSCIENTIST | 2005年 / 11卷 / 06期

关键词：

potassium channels; memory lymphocytes; autoimmunity; multiple sclerosis; Kv1.3;

D O I：

10.1177/1073858405278016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K+ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.

引用

页码：550 / 562

页数：13

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