Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light

被引：42

作者：

Janczyk, Agnieszka ^{[1
]}

Wolnicka-Glubisz, Agnieszka ^{[2
]}

Urbanska, Krystyna ^{[2
]}

Kisch, Horst

Stochel, Grazyna ^{[1
]}

Macyk, Wojciech ^{[1
]}

机构：

[1] Jagiellonian Univ, Fac Chem, Ingardena 3, PL-30060 Krakow, Poland

[2] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Biophys, PL-30349 Krakow, Poland

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2008年 / 44卷 / 06期

关键词：

reactive oxygen species; titanium dioxide; photocatalysis; phototoxicity; photodynamic therapy; mouse melanoma;

D O I：

10.1016/j.freeradbiomed.2007.12.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The visible light-induced phototoxicity of titanium dioxide modified with platinum(I-V) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species ((OH)-O-center dot, O-2(center dot-), H2O2, O-1(2)) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda > 455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1120 / 1130

页数：11

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