The role of the macrophage in immune regulation

被引:171
作者
Gordon, S [1 ]
机构
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源
RESEARCH IN IMMUNOLOGY | 1998年 / 149卷 / 7-8期
基金
英国惠康基金;
关键词
macrophage; dendritic cell; in vivo and in vitro immune regulation; review;
D O I
10.1016/S0923-2494(99)80039-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The macrophage plays an important role in both the innate and acquired (humoral and cellular) immune responses. Their specialized derivatives, the dendritic cells (DCs), are uniquely potent in induction of naive T and B lymphocytes, whereas macrophages influence a range of immune responses by antigen recognition, capture, clearance and transport. They recruit haemopoietic cells to local sites of inflammation and immunity and regulate their activities. We have used various myeloid-restricted membrane antigens and receptors as markers and functional contributors to these activities, and briefly review their role in immune regulation in vivo and in vitro.
引用
收藏
页码:685 / 688
页数:4
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