The perichromatin region: A functional compartment in the nucleus that determines large-scale chromatin folding

被引：56

作者：

Fakan, Stanislav ^{[1
]}

van Driel, Roel ^{[2
,3
]}

机构：

[1] Univ Lausanne, Ctr Electron Microscopy, CH-1005 Lausanne, Switzerland

[2] Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 SM Amsterdam, Netherlands

[3] Univ Amsterdam, Netherlands Inst Syst Biol, NL-1098 SM Amsterdam, Netherlands

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 05期

关键词：

perichromatin; transcription; replication; nuclear organization; electron microscopy;

D O I：

10.1016/j.semcdb.2007.08.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The perichromatin region has emerged as an important functional domain of the interphase nucleus. Major nuclear functions, such as DNA replication and transcription, as well as different RNA processing factors, occur within this domain. In this review, we summarize in situ observations regarding chromatin structure analysed by transmission electron microscopy and compare results to data obtained by other methods. In particular, we address the functional architecture of the perichromatin region and the way chromatin may be folded within this nucleoplasmic domain. (C) 2007 Published by Elsevier Ltd.

引用

页码：676 / 681

页数：6

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