TET2 mutations in secondary acute myeloid leukemias: a French retrospective study

被引：33

作者：

Kosmider, Olivier ^{[1
,2
,3
,4
,5
]}

Delabesse, Eric ^{[6
]}

Mansat-De Mas, Veronique ^{[6
]}

Cornillet-Lefebvre, Pascale ^{[7
]}

Blanchet, Odile ^{[8
,9
]}

Delmer, Alain ^{[10
]}

Recher, Christian ^{[11
]}

Raynaud, Sophie ^{[12
]}

Bouscary, Didier ^{[1
,2
,3
,4
,13
]}

Viguie, Franck ^{[5
,14
]}

Lacombe, Catherine ^{[1
,2
,3
,4
,5
]}

Bernard, Olivier A. ^{[15
]}

Ifrah, Norbert ^{[16
]}

Dreyfus, Francois ^{[2
,3
,4
,5
,13
]}

Fontenay, Michaela ^{[1
,2
,3
,4
,5
]}

机构：

[1] Hop Broca Cochin Hotel Dieu, Serv Hematol Biol, AP HP, Paris, France

[2] Inst Cochin, Dept Immunohematol, Paris, France

[3] INSERM, U1016, Paris, France

[4] CNRS, UMR 8104, Paris, France

[5] Univ Paris 05, Fac Med, Paris, France

[6] CHU Purpan, Hematol Lab, Toulouse, France

[7] CHU Reims, Hematol Lab, Reims, France

[8] CHU Angers, Hematol Lab, Angers, France

[9] INSERM, U892, Paris, France

[10] CHU Reims, Serv Hematol Clin, Hop Robert Debre, Reims, France

[11] CHU Purpan, Hematol Serv, Toulouse, France

[12] CHU Archet, Lab Hematol & Cytogenet, Nice, France

[13] Hop Cochin, AP HP, Unite Fonct Hematol, Dept Med Interne, F-75674 Paris, France

[14] Hop St Antoine, AP HP, Serv Hematol Biol, Paris, France

[15] Inst Gustave Roussy, INSERM, U985, F-94805 Villejuif, France

[16] CHU Angers, Serv Malad Sang, Angers, France

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 07期

关键词：

secondary AML; TET2; mutations; characteristics; prognosis; 5-METHYLCYTOSINE; HETEROZYGOSITY; KARYOTYPE; FREQUENT; COMMON; GENE; MDS;

D O I：

10.3324/haematol.2011.040840

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ten-eleven translocation 2 (TET2) mutations have been involved in myeloid malignancies. This retrospective study aims at evaluating the frequency and impact of TET2 mutations in 247 secondary acute myeloid leukemia cases referred to as myelodysplasia-related changes (n = 201) or therapy-related (n = 46) leukemias. Mutation of at least one copy of the TET2 gene was detected in 49 of 247 (19.8%) patients who presented with older age, higher hemoglobin level, higher neutrophil and monocyte counts, and lower platelet count. TET2 mutations were significantly less frequent in therapy-related (8.7%) than myelodysplasia-related changes (22.3%; P = 0.035) leukemias and strongly associated with normal karyotype (P < 0.001). TET2 mutations did not significantly associate with NPM1, FLT3-ITD or FLT3-D835, WT1, or N- or K-RAS mutations. Complete remission was achieved in 57% of evaluable patients who had received intensive chemotherapy. In this group, TET2 mutations did not influence the complete remission rate or overall survival.

引用

页码：1059 / 1063

页数：5

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