A postulated role for microRNA in cellular differentiation

被引：31

作者：

Bentwich, I ^{[1
]}

机构：

[1] Rosetta Genom, IL-76706 Rehovot, Israel

来源：

FASEB JOURNAL | 2005年 / 19卷 / 08期

关键词：

embryogenesis; UTR; genomic module; protein coding genes; microRNA gene cluster;

D O I：

10.1096/fj.04-3609hyp

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past two decades a variety of mechanisms regulating cellular differentiation have been uncovered. These include signaling by morphogens or membrane-associated ligands and asymmetric segregation of cytoplasmic components. Most of these processes are driven by protein coding genes. Here I describe another possible cellular differentiation mechanism that involves asymmetric segregation of micro RNAs, a group of recently discovered non-protein coding genes that have been shown to be involved in differentiation.-Bentwich, I. A postulated role for microRNA in cellular differentiation.

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收藏

页码：875 / 879

页数：5

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