Trends in human birth weight across two successive generations

被引:25
作者
Agnihotri, B. [1 ]
Antonisamy, B. [2 ]
Priya, G. [2 ]
Fall, C. H. D. [3 ]
Raghupathy, P. [1 ]
机构
[1] Christian Med Coll & Hosp, Dept Child Hlth, Vellore, Tamil Nadu, India
[2] Christian Med Coll & Hosp, Dept Biostat, Vellore, Tamil Nadu, India
[3] Southampton Gen Hosp, MRC Epidemiol Resource Ctr, Southampton SO9 4XY, Hants, England
基金
英国医学研究理事会;
关键词
intergenerational study; low birth weight; birth cohort;
D O I
10.1007/s12098-008-0066-x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective. To determine the correlation between parental and offspring birthweight (BW) in India. Methods. The study involved two birth cohorts of successive generations. The parental cohort comprised of 472 fathers and 422 mothers from an earlier study. Details of their anthropometry at birth and in adulthood were available. 1525 children born to them comprised the offspring cohort. BW was obtained from hospital records for the offspring cohort. Odds ratios and regression coefficients were calculated to estimate the risks of a low birth weight (LBW) parent producing a LBW baby and quantitate the effects after adjusting for confounders. Results. A LBW mother had a 2.8 times risk (95% Cl 1.2-6.4) of delivering a LBW baby (p=0.02) and a LBW father was twice as likely to produce a LBW baby (OR 2.2; 95%Cl 1.0-4.8; p=0.05). Every 100g increase in maternal BW was associated with an increase in offspring BW of 14g; the equivalent figure for paternal BW was 18.1g (p<0.001 for both). Between the generations, the incidence of LBW decreased from 19.7% to 17.2% (p=0.1). Mean BW increased in males (2846 g vs 2861 g; p=0.59) but not in females (2790 g vs 2743 g; p=0.08). Conclusion. Both maternal and paternal BW are strong determinants of offspring BW. The effect of mothers' BW on offspring BW is weaker than that seen in developed nations. Stronger intrauterine constraint exhibited by Indian women secondary to a higher prevalence of growth restriction in utero may be responsible. Paternal effects may be governed by paternal genes inherited by the offspring.
引用
收藏
页码:111 / 117
页数:7
相关论文
共 36 条
[1]  
Alberman E, 1992, Paediatr Perinat Epidemiol, V6, P134, DOI 10.1111/j.1365-3016.1992.tb00755.x
[2]  
BOOKS AA, 1995, EARLY HUM DEV, V42, P29
[3]   IS BIRTH-WEIGHT DETERMINED GENETICALLY [J].
CARRHILL, R ;
CAMPBELL, DM ;
HALL, MH ;
MEREDITH, A .
BRITISH MEDICAL JOURNAL, 1987, 295 (6600) :687-689
[4]  
Coutinho R, 1997, AM J EPIDEMIOL, V146, P804
[5]   PARENTAL IMPRINTING OF THE MOUSE INSULIN-LIKE GROWTH FACTOR-II GENE [J].
DECHIARA, TM ;
ROBERTSON, EJ ;
EFSTRATIADIS, A .
CELL, 1991, 64 (04) :849-859
[6]   Association of the INS VNTR with size at birth [J].
Dunger, DB ;
Ong, KKL ;
Huxtable, SJ ;
Sherriff, A ;
Woods, KA ;
Ahmed, ML ;
Golding, J ;
Pembrey, ME ;
Ring, S ;
Bennett, ST ;
Todd, JA .
NATURE GENETICS, 1998, 19 (01) :98-100
[7]   INTERGENERATIONAL STUDIES OF HUMAN BIRTH-WEIGHT FROM THE 1958 BIRTH COHORT .1. EVIDENCE FOR A MULTIGENERATIONAL EFFECT [J].
EMANUEL, I ;
FILAKTI, H ;
ALBERMAN, E ;
EVANS, SJW .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (01) :67-74
[8]  
Fisher R. A., 1919, Transactions of the Royal Society of Edinburgh, V52
[9]   The role of genetic susceptibility in the association of low birth weight with type 2 diabetes [J].
Frayling, TM ;
Hattersley, AT .
BRITISH MEDICAL BULLETIN, 2001, 60 :89-101
[10]   Maternal birthweight and diet in pregnancy in relation to the infant's thinness at birth [J].
Godfrey, KM ;
Barker, DJP ;
Robinson, S ;
Osmond, C .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1997, 104 (06) :663-667