Assay of sertraline in tablets and drug substance by liquid chromatography

被引：15

作者：

Adams, AIH ^{[1
]}

Bergold, AM ^{[1
]}

机构：

[1] UFRGS, Curso Pos Grad Ciencias Farmaceut, BR-90610000 Porto Alegre, RS, Brazil

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 26卷 / 03期

关键词：

sertraline; high-performance liquid chromatography assay; quality control;

D O I：

10.1016/S0731-7085(01)00425-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatography isocratic procedure was developed for the assay of sertraline in drug substance and tablets. The chromatographic system consists of a RP-8 column (125 x 4 mm, 5 mum). a mobile phase composed of acetonitrile and sodium phosphate buffer, pH 5.5 (7:3), flow rate of 1.0 ml.min(-1) and UV detection at 270 nm. The method validation yielded good results. The coefficient of variation varied between 0.19 and 1.04% and accuracy of 99.18% was found. Calibration curve was linear between 0.5 and 2.5 mg.ml(-1); its correlation coefficient was 0.9999. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：505 / 508

页数：4

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