Safe of inhaled corticosteroids delivered by plastic and meta spacers

被引:5
作者
Amirav, I
Mansour, Y
Tiosano, T
Chamny, S
Chirurg, S
Oren, S
Grossman, Z
Kahana, L
Kahan, E
Newhouse, MT
机构
[1] Schneider Childrens Med Ctr Israel, Petah Tiqwa, Israel
[2] McMaster Univ, Hamilton, ON, Canada
关键词
D O I
10.1136/adc.88.6.527
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Because of its non-electrostatic properties the metal Nebuchamber (NC) valved holding chamber (VHC) delivers a greater mass of aerosol to the mouth than the polypropylene Aerochamber (AC) VHC. Delivery of more aerosol to the lungs may also increase systemic absorption of inhaled corticosteroids (ICS) and hypothalamo-pituitary-adrenal (HPA) suppression. Methods: Thirty children (mean 4.3 (SD 0.3) years) received 200 mug budesonide twice daily by NC or AC, both with the mask provided, in a randomised, two month crossover trial. Twenty four hour urinary free cortisol (UFC) was determined as a measure of HPA suppression. Results: UFC decreased from 42.3 (7.8) nmol UFC/nmol creatinine control to 26.2 (2.4) (p = 0.06 v control) after AC, and to 24.5 (2.5) (p = 0.04 v control) after NC (p = 0.4 AC v NC). Conclusions: Despite a greater total dose delivered to the mouth, NC is not associated with greater HPA suppression when using 400 mug/day budesonide under real life conditions in young children.
引用
收藏
页码:527 / 528
页数:2
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