Synthesis and incorporation of an N-acetylcysteamine analogue of methylmalonyl-CoA by a modular polyketide synthase

被引：31

作者：

Pohl, NL

Gokhale, RS

Cane, DE

Khosla, C

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

[2] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 43期

关键词：

D O I：

10.1021/ja9830290

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：11206 / 11207

页数：2

共 21 条

[1]

ARNSTADT KI, 1976, LIEBIGS ANN CHEM, P843

[2] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN [J].

CANE, DE ;

YANG, CC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) :1255-1257

[3] MACROLIDE BIOSYNTHESIS .7. INCORPORATION OF POLYKETIDE CHAIN ELONGATION INTERMEDIATES INTO METHYMYCIN [J].

CANE, DE ;

LAMBALOT, RH ;

PRABHAKARAN, PC ;

OTT, WR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (02) :522-526

[4] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].

CORTES, J ;

HAYDOCK, SF ;

ROBERTS, GA ;

BEVITT, DJ ;

LEADLAY, PF .

NATURE, 1990, 348 (6297) :176-178

[5] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

SCIENCE, 1991, 252 (5006) :675-679

[6] SYNTHESIS OF BETA-KETO AND ALPHA,BETA-UNSATURATED N-ACETYLCYSTEAMINE THIOESTERS [J].

GILBERT, IH ;

GINTY, M ;

ONEILL, JA ;

SIMPSON, TJ ;

STAUNTON, J ;

WILLIS, CL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (15) :1587-1590

[7] Genetic contributions to understanding polyketide synthases [J].

Hopwood, DA .

CHEMICAL REVIEWS, 1997, 97 (07) :2465-2497

[8] THE REDUCTIVE ALKYLATION OF MELDRUM ACID [J].

HRUBOWCHAK, DM ;

SMITH, FX .

TETRAHEDRON LETTERS, 1983, 24 (45) :4951-4954

[9] Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis [J].

Jacobsen, JR ;

Cane, DE ;

Khosla, C .

BIOCHEMISTRY, 1998, 37 (14) :4928-4934

[10] ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE [J].

KAO, CM ;

LUO, GL ;

KATZ, L ;

CANE, DE ;

KHOSLA, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (25) :11612-11613

← 1 2 3 →