SYNTHESIS OF BETA-KETO AND ALPHA,BETA-UNSATURATED N-ACETYLCYSTEAMINE THIOESTERS

被引：41

作者：

GILBERT, IH

GINTY, M

ONEILL, JA

SIMPSON, TJ

STAUNTON, J

WILLIS, CL

机构：

[1] UNIV BRISTOL,SCH CHEM,BRISTOL BS8 1TS,AVON,ENGLAND

[2] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00276-Y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methods for the synthesis of N-acetylcysteamine thioesters of beta-keto and alpha,beta-unsaturated acids which avoid problems associated with methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from reaction mixtures using copper sulphate impregnated silica.

引用

页码：1587 / 1590

页数：4

共 13 条

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