Synthesis and characterization of flavin-tethered peptide nucleic acid

被引：26

作者：

Ikeda, H ^{[1
]}

Yoshida, K ^{[1
]}

Ozeki, M ^{[1
]}

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, CREST,Japan Sci & Technol Corp, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(01)00228-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We synthesized flavin-containing PNA. monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2529 / 2531

页数：3

共 37 条

[1] Hairpin-forming peptide nucleic acid oligomers
Armitage, B
Ly, D
Koch, T
Frydenlund, H
Orum, H
Schuster, GB
[J]. BIOCHEMISTRY, 1998, 37 (26) : 9417 - 9425
[2] Deoxynucleic guanidines/PNA (DNG/PNA) chimeras: Oligonucleoside analogue containing cationic guanidinium and neutral amide linkages
Barawkar, DA
Bruice, TC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (44) : 10418 - 10419
[3] PHOTOENZYMES - A NOVEL CLASS OF BIOLOGICAL CATALYSTS
BEGLEY, TP
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1994, 27 (12) : 394 - 401
[4] PEPTIDE NUCLEIC-ACIDS AND THEIR POTENTIAL APPLICATIONS IN BIOTECHNOLOGY
BUCHARDT, O
EGHOLM, M
BERG, RH
NIELSEN, PE
[J]. TRENDS IN BIOTECHNOLOGY, 1993, 11 (09) : 384 - 386
[5] SUNLIGHT-DAMAGED DNA REPAIRED WITH SUNLIGHT
CARELL, T
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (22): : 2491 - 2494
[6] Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids
Challa, H
Woski, SA
[J]. TETRAHEDRON LETTERS, 1999, 40 (48) : 8333 - 8336
[7] Christensen L, 1995, J Pept Sci, V1, P175
[8] Synthesis of new building blocks: Towards the analogs of peptide nucleic acids (PNAs)
Dallaire, C
Arya, P
[J]. TETRAHEDRON LETTERS, 1998, 39 (29) : 5129 - 5132
[9] DEMIDOV V, 1994, BIOCHEM PHARMACOL, V48, P1309
[10] SYNTHESIS OF PEPTIDE NUCLEIC-ACID MONOMERS CONTAINING THE 4 NATURAL NUCLEOBASES - THYMINE, CYTOSINE, ADENINE, AND GUANINE AND THEIR OLIGOMERIZATION
DUEHOLM, KL
EGHOLM, M
BEHRENS, C
CHRISTENSEN, L
HANSEN, HF
VULPIUS, T
PETERSEN, KH
BERG, RH
NIELSEN, PE
BUCHARDT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (19) : 5767 - 5773

← 1 2 3 4 →