Gleason grade remains an important prognostic predictor in men diagnosed with prostate cancer while on finasteride therapy

The controversial topic of the effect of finasteride therapy on Gleason grade, raised by the Prostate Cancer Prevention Trial, is discussed by authors from New York. They assessed a series of patients who had been treated with finasteride, and who subsequently had a radical prostatectomy, to see if this pharmaceutical agent prevented accurate Gleason grade assignment and prediction of biochemical recurrence. They found that Gleason grade remains an important prognostic predictor in men diagnosed with prostate cancer while on finasteride therapy. Authors from Amsterdam assessed the accuracy of ultrasonography-guided fine-needle aspiration cytology as a method of detecting occult lymph node metastases in patients with penile cancer, and found that it can be used as an initial investigation in such patients, with helpful clinical outcomes.