Substitution and cyclization reactions involving the quasi-antiaromatic 2H-indol-2-one ring system

被引：68

作者：

England, Dylan B. ^{[1
]}

Merey, Gokce ^{[1
]}

Padwa, Albert ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 19期

关键词：

D O I：

10.1021/ol7016438

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The quasi-antiaromatic 2H-indol-2-one ring system is readily generated by treating a 3-hydroxy-substituted 1,3-dihydroindol-2-one with a Lewis acid. Stepwise addition of various pi-nucleophiles to the highly reactive 2H-indol-2-one system occurs smoothly to afford substituted oxindoles. The cyclization was also carried out in an intramolecular fashion to give spiro-substituted oxindoles in good yield.

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页码：3805 / 3807

页数：3

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