Alkyne cross metathesis reactions of extended scope

被引:71
作者
Furstner, A [1 ]
Mathes, C [1 ]
机构
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
关键词
D O I
10.1021/ol0068795
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] A catalyst formed in situ from Mo[N(t-Bu)(Ar)](3) 1 (Ar = 3,5-dimethylphenyl) and CH2Cl2 in toluene effects cross metathesis reactions of functionalized alkynes that are beyond reach of more traditional promoters. An application to the synthesis of prostaglandin E-2 (PGE(2)) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates.
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页码:221 / 223
页数:3
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