Alkyne cross metathesis reactions of extended scope

被引：71

作者：

Furstner, A ^{[1
]}

Mathes, C ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 02期

关键词：

D O I：

10.1021/ol0068795

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A catalyst formed in situ from Mo[N(t-Bu)(Ar)](3) 1 (Ar = 3,5-dimethylphenyl) and CH2Cl2 in toluene effects cross metathesis reactions of functionalized alkynes that are beyond reach of more traditional promoters. An application to the synthesis of prostaglandin E-2 (PGE(2)) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates.

引用

页码：221 / 223

页数：3

共 34 条

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