Histone deacetylase inhibitors mediate post-transcriptional regulation of p21WAF1 through novel cis-acting elements in the 3′ untranslated region

被引：4

作者：

Hirsch, Calley L. ^{[1
]}

Ellis, Danielle J. P. ^{[1
]}

Bonham, Keith ^{[2
,3
]}

机构：

[1] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7N 5E5, Canada

[2] Saskatchewan Canc Agcy, Canc Res Unit, Hlth Res Div, Saskatoon, SK S7N 4H4, Canada

[3] Univ Saskatchewan, Div Oncol, Coll Med, Saskatoon, SK S7N 4H4, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 402卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Histone deacetylase inhibitors; p21(WAF1); mRNA stability; 3 ' untranslated region; MESSENGER-RNA STABILITY; WAF1/CIP1 GENE PROMOTER; COLON-CANCER CELLS; HDAC INHIBITORS; 3'-UNTRANSLATED REGION; BINDING PROTEIN; HEPG2; CELLS; SP1; SITES; EXPRESSION; HUR;

D O I：

10.1016/j.bbrc.2010.10.085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone deacetylase inhibitors (HDACIs) are promising anti-tumor agents that selectively Induce cell cycle arrest differentiation and/or apoptosis of tumor cells Fundamentally HDACIs are proposed to function by activating the transcription of genes including the potent cyclin dependent kinase inhibitor p21(WAF1) However HDACIs primarily increase p21(WAF1) expression at the post-transcriptional level in HepG2 cells implying that these anti-tumor agents regulate genes at multiple levels Here two novel as-acting elements in the 3' untranslated region (UTR) of p21(WAF1) are identified that control the ability of HDACIs to induce p21(WAF1) mRNA stabilization Collectively these studies highlight the complexity of HDACIs in gene regulation (C) 2010 Elsevier Inc All rights reserved

引用

页码：687 / 692

页数：6

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