The autoimmune tautology

被引：77

作者：

Anaya, Juan-Manuel ^{[1
]}

机构：

[1] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res CREA, Bogota 111221, Colombia

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 06期

关键词：

HERITABILITY;

D O I：

10.1186/ar3175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune diseases within an individual (that is, polyautoimmunity) and within members of a nuclear family (that is, familial autoimmunity). Second, physiopathologic evidence indicates that the pathologic mechanisms may be similar among autoimmune diseases. Lastly, genetic evidence shows that autoimmune phenotypes might represent pleiotropic outcomes of the interaction of non-specific disease genes.

引用

页数：3

共 12 条

[1]

Anaya Juan-Manuel, 2007, Expert Rev Clin Immunol, V3, P623, DOI 10.1586/1744666X.3.4.623

[2] Is there a common genetic basis for autoimmune diseases? [J].

Anaya, Juan-Manuel ;

Gomez, Luismiguel ;

Castiblanco, John .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2006, 13 (2-4) :185-195

[3] Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases [J].

Becker, KG ;

Simon, RM ;

Bailey-Wilson, JE ;

Freidlin, B ;

Biddison, WE ;

McFarland, HF ;

Trent, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :9979-9984

[4] Genetics of rheumatic disease [J].

Clarke, Alex ;

Vyse, Timothy J. .

ARTHRITIS RESEARCH & THERAPY, 2009, 11 (05)

[5]

DELGADOVEGA A, 2010, CURRENT OPINION 1006

[6] Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease [J].

Eyre, Stephen ;

Hinks, Anne ;

Bowes, John ;

Flynn, Edward ;

Martin, Paul ;

Wilson, Anthony G. ;

Morgan, Ann W. ;

Emery, Paul ;

Steer, Sophia ;

Hocking, Lynne J. ;

Reid, David M. ;

Harrison, Pille ;

Wordsworth, Paul ;

Thomson, Wendy ;

Worthington, Jane ;

Barton, Anne .

ARTHRITIS RESEARCH & THERAPY, 2010, 12 (05)

[7]

LIEBMAN MN, 2002, SCI STKE, pPE20

[8] Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases [J].

Mamtani, M. ;

Anaya, J-M ;

He, W. ;

Ahuja, S. K. .

GENES AND IMMUNITY, 2010, 11 (02) :155-160

[9] Finding the missing heritability of complex diseases [J].

Manolio, Teri A. ;

Collins, Francis S. ;

Cox, Nancy J. ;

Goldstein, David B. ;

Hindorff, Lucia A. ;

Hunter, David J. ;

McCarthy, Mark I. ;

Ramos, Erin M. ;

Cardon, Lon R. ;

Chakravarti, Aravinda ;

Cho, Judy H. ;

Guttmacher, Alan E. ;

Kong, Augustine ;

Kruglyak, Leonid ;

Mardis, Elaine ;

Rotimi, Charles N. ;

Slatkin, Montgomery ;

Valle, David ;

Whittemore, Alice S. ;

Boehnke, Michael ;

Clark, Andrew G. ;

Eichler, Evan E. ;

Gibson, Greg ;

Haines, Jonathan L. ;

Mackay, Trudy F. C. ;

McCarroll, Steven A. ;

Visscher, Peter M. .

NATURE, 2009, 461 (7265) :747-753

[10] Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis [J].

Rojas-Villarraga, Adriana ;

Diaz, Francisco J. ;

Calvo-Paramo, Enrique ;

Salazar, Juan C. ;

Iglesias-Gamarra, Antonio ;

Mantilla, Ruben D. ;

Anaya, Juan-Manuel .

JOURNAL OF AUTOIMMUNITY, 2009, 32 (01) :64-69

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