Photoaging and oxidative stress

被引：49

作者：

Nishigori, C

Hattori, Y

Arima, Y

Miyachi, Y

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Sakyo Ku, Kyoto 6068507, Japan

[2] Kobe Univ, Grad Sch Med, Dept Dermatol, Kobe, Hyogo 657, Japan

来源：

EXPERIMENTAL DERMATOLOGY | 2003年 / 12卷

关键词：

8-OHdG; hairless mice; oxidative stress; pentosidine; photoaging;

D O I：

10.1034/j.1600-0625.12.s2.3.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Photoaging is significantly different from chronological aging in both clinical and histological appearance. It has been suggested that oxidative stress, generated by ultraviolet radiation (UVR), leads to photoaging over a long period. The presence of 8-OHdG, and oxidatively modified proteins such as 4-hydroxy-2-nonenal-modified protein, 3-L-nitro-tyrosine and N-epsilon(carboxymethyl)lysine in UV-exposed skin specimens, supports this theory. The pathophysiology of photoaging of the skin caused by chronic inflammation after UVR is reviewed and discussed, with a focus on oxidative stress.

引用

页码：18 / 21

页数：4

共 15 条

[1] Role of oxidative stress in diabetic complications - A new perspective on an old paradigm [J].