Total synthesis of himandravine

被引：31

作者：

Chackalamannil, S

Davies, R

McPhail, AT

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

[2] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 10期

关键词：

D O I：

10.1021/ol010038w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first total synthesis of (+)-himandravine (1) is described, starting from (2S,6S)-cis-2-formyl-6-methyl-N-Boc-piperidine (8) in 11 linear steps and 17% overall yield. The key step involves a highly diastereoselective intramolecular Diels-Alder reaction of the key intermediate 5 that contains the entire latent carbon framework and functional group substitution of himandravine.

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页码：1427 / 1429

页数：3

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