New synthesis of optically active 5-isoxazolidinones and β-amino acids

被引：32

作者：

Luisi, R

Capriati, V

Florio, S

Vista, T

机构：

[1] Univ Bari, Dipartimento Farmacochim, I-70126 Bari, Italy

[2] CNR, ICCOM, Bari, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 25期

关键词：

D O I：

10.1021/jo035356i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of beta-amino acids.

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页码：9861 / 9864

页数：4

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