The Extended Granin Family: Structure, Function, and Biomedical Implications

被引：252

作者：

Bartolomucci, Alessandro ^{[1
]}

Possenti, Roberta ^{[2
]}

Mahata, Sushil K. ^{[3
]}

Fischer-Colbrie, Reiner ^{[4
]}

Loh, Y. Peng ^{[5
]}

Salton, Stephen R. J. ^{[6
]}

机构：

[1] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA

[2] Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy

[3] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[4] Innsbruck Med Univ, Dept Pharmacol, A-6020 Innsbruck, Austria

[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cellular Neurobiol Sect, Program Dev Neurosci, NIH, Bethesda, MD 20892 USA

[6] Mt Sinai Sch Med, Brookdale Dept Geriatr & Palliat Med, Fishberg Dept Neurosci, New York, NY 10029 USA

来源：

ENDOCRINE REVIEWS | 2011年 / 32卷 / 06期

基金：

美国国家卫生研究院;

关键词：

SECRETORY GRANULE BIOGENESIS; AMYOTROPHIC-LATERAL-SCLEROSIS; VGF-DERIVED PEPTIDE; PLASMA CHROMOGRANIN-A; PROHORMONE CONVERTASE PC2; CENTRAL-NERVOUS-SYSTEM; DISULFIDE-BONDED LOOP; C-TERMINAL FRAGMENT; NEUROENDOCRINE POLYPEPTIDE 7B2; CARDIAC NATRIURETIC PEPTIDES;

D O I：

10.1210/er.2010-0027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) that together comprise the granin family subserve essential roles in the regulated secretory pathway that is responsible for controlled delivery of peptides, hormones, neurotransmitters, and growth factors. Here we review the structure and function of granins and granin-derived peptides and expansive new genetic evidence, including recent single-nucleotide polymorphism mapping, genomic sequence comparisons, and analysis of transgenic and knockout mice, which together support an important and evolutionarily conserved role for these proteins in large dense-core vesicle biogenesis and regulated secretion. Recent data further indicate that their processed peptides function prominently in metabolic and glucose homeostasis, emotional behavior, pain pathways, and blood pressure modulation, suggesting future utility of granins and granin-derived peptides as novel disease biomarkers. (Endocrine Reviews 32: 755-797, 2011)

引用

页码：755 / 797

页数：43

共 432 条

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