Education and occupations preceding Parkinson disease - A population-based case-control study

被引:113
作者
Frigerio, R
Elbaz, A
Sanft, KR
Peterson, BJ
Bower, JH
Ahlskog, JE
Grossardt, BR
de Andrade, M
Maraganore, DM
Rocca, WA
机构
[1] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN 55905 USA
[3] Hop La Pitie Salpetriere, Inserm Unit 708, Paris, France
关键词
D O I
10.1212/01.wnl.0000184520.21744.a2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To investigate the association of Parkinson disease ( PD) with education and occupations using a case- control study design. Methods: The authors used the medical records- linkage system of the Rochester Epidemiology Project to identify all subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age ( +/- 1 year) and sex to a general population control. The authors collected information about education and occupations using two independent sources of data: a review of the complete medical records in the system and a telephone interview. Occupations were coded using the 1980 Standard Occupational Classification. Results: Subjects with 9 or more years of education were at increased risk of PD ( OR = 2.0; 95% CI = 1.1 to 3.6; p = 0.02), and there was a trend of increasing risk with increasing education ( test for linear trend, p = 0.02; medical records data). Physicians were at significantly increased risk of PD using both sources of occupational data. By contrast, four occupational groups showed a significantly decreased risk of PD using one source of data: construction and extractive workers ( e. g., miners, oil well drillers), production workers ( e. g., machine operators, fabricators), metal workers, and engineers. These associations with increased or decreased risk did not change noticeably after adjustment for education. Conclusion: Subjects with higher education and physicians have an increased risk of Parkinson disease ( PD), while subjects with some occupations presumed to involve high physical activity have a decreased risk of PD.
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页码:1575 / 1583
页数:9
相关论文
共 43 条
[31]   BIAS IN ANALYTIC RESEARCH [J].
SACKETT, DL .
JOURNAL OF CHRONIC DISEASES, 1979, 32 (1-2) :51-63
[32]   Neurodegenerative diseases: Occupational occurrence and potential risk factors, 1982 through 1991 [J].
Schulte, PA ;
Burnett, CA ;
Boeniger, MF .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1996, 86 (09) :1281-1288
[33]   Possible environmental, occupational, and other etiologic factors for Parkinson's disease: A case-control study in Germany [J].
Seidler, A ;
Hellenbrand, W ;
Robra, BP ;
Vieregge, P ;
Nischan, P ;
Joerg, J ;
Oertel, WH ;
Ulm, G ;
Schneider, E .
NEUROLOGY, 1996, 46 (05) :1275-1284
[34]  
Szklo M., 2014, Epidemiology: Beyond the basics, V2nd
[35]  
Tanner CM, 2003, ADV NEUROL, V91, P133
[36]   ENVIRONMENTAL-FACTORS AND PARKINSONS-DISEASE - A CASE-CONTROL STUDY IN CHINA [J].
TANNER, CM ;
CHEN, B ;
WANG, W ;
PENG, M ;
LIU, Z ;
LIANG, X ;
KAO, LC ;
GILLEY, DW ;
GOETZ, CG ;
SCHOENBERG, BS .
NEUROLOGY, 1989, 39 (05) :660-664
[37]  
Taylor CA, 1999, AM J MED GENET, V88, P742, DOI 10.1002/(SICI)1096-8628(19991215)88:6<742::AID-AJMG29>3.3.CO
[38]  
2-R
[39]   Occupational risk factors in Parkinson's disease [J].
Tsui, JKC ;
Calne, DB ;
Wang, Y ;
Schulzer, M ;
Marion, SA .
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE, 1999, 90 (05) :334-337
[40]  
*US DEP COMM OFF F, 1980, STAND OCC CLASS MAN