α-Galactosylceramide:: Potential immunomodulatory activity and future application

被引：58

作者：

Hayakawa, Y

Godfrey, DI

Smyth, MJ

机构：

[1] Peter MacCallum Canc Ctr, Trescowthick Labs, Canc Immunol Program, Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

CURRENT MEDICINAL CHEMISTRY | 2004年 / 11卷 / 02期

关键词：

D O I：

10.2174/0929867043456115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Galactosylceramide (alpha-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. alpha-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-gamma and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of alpha-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of alpha-GalCer and its possible future application for clinical studies in humans.

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页码：241 / 252

页数：12

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