Nisin biosynthesis and its properties

被引：137

作者：

Cheigh, CI

Pyun, YR ^{[1
]}

机构：

[1] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea

[2] Yonsei Univ, R&D Div, Biovan Co Ltd, Seoul 120749, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 21期

关键词：

nisin; nisin biosynthesis; nisin-mediated induction; regulation; two-component regulatory system;

D O I：

10.1007/s10529-005-2721-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The antimicrobial peptide, nisin, produced by several strains of Lactococcus lactis, which belongs to the Class I bacteriocins called lantibiotics, is a small (3.4 kDa), 34-amino acid, cationic, hydrophobic peptide and has the five characteristic (beta-methyl)lanthionine rings formed by significant post-translational modification. A cluster of 11 genes has been involved in the biosynthesis of nisin and are proposed to be transcriptionally arranged as nisA(Z)BTCIP, nisRK, and nisFEG. The biosynthesis of nisin is regulated in a growth-phase-dependent manner including nisin-mediated induction which occurs via NisRK two-component regulatory system. This review outlines some of the more recent developments in the properties, regulation and applications of nisin biosynthesis.

引用

页码：1641 / 1648

页数：8

共 59 条

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