The first synthesis of the epoxide-containing macrolactone nucleus of oximidine I

被引：16

作者：

Harvey, JE ^{[1
]}

Raw, SA ^{[1
]}

Taylor, RJK ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 38期

关键词：

oximidine; Horner-Wadsworth-Emmons; epoxide;

D O I：

10.1016/S0040-4039(03)01775-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-l-ol. The key macrocyclisation step is achieved using Homer-Wadsworth-Emmons methodology in the presence of an epoxide. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7209 / 7212

页数：4

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