Fcγ receptors as regulators of immune responses

被引：2242

作者：

Nimmerjahn, Falk ^{[1
]}

Ravetch, Jeffrey V. ^{[2
]}

机构：

[1] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Lab Expt Immunol & Immunotherapy, D-91054 Erlangen, Germany

[2] Rockefeller Univ, Lab Mol Genet & Immunol, New York, NY 10021 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in understanding the mechanisms that regulate the activity of IgG antibodies in vivo. In this Review, we discuss recent studies addressing the multifaceted roles of FcRs for IgG (Fc gamma Rs) in the immune system and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases.

引用

页码：34 / 47

页数：14

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