Fcγ receptors as regulators of immune responses

被引：2242

作者：

Nimmerjahn, Falk ^{[1
]}

Ravetch, Jeffrey V. ^{[2
]}

机构：

[1] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Lab Expt Immunol & Immunotherapy, D-91054 Erlangen, Germany

[2] Rockefeller Univ, Lab Mol Genet & Immunol, New York, NY 10021 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in understanding the mechanisms that regulate the activity of IgG antibodies in vivo. In this Review, we discuss recent studies addressing the multifaceted roles of FcRs for IgG (Fc gamma Rs) in the immune system and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases.

引用

页码：34 / 47

页数：14

共 135 条

[21] CYTOTOXIC ANTIBODIES TRIGGER INFLAMMATION THROUGH FC-RECEPTORS [J].

CLYNES, R ;

RAVETCH, JV .

IMMUNITY, 1995, 3 (01) :21-26

[22] Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction [J].

Corper, AL ;

Sohi, MK ;

Bonagura, VR ;

Steinitz, M ;

Jefferis, R ;

Feinstein, A ;

Beale, D ;

Taussig, MJ ;

Sutton, BJ .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (05) :374-381

[23] INFUSION OF FC-GAMMA-FRAGMENTS FOR TREATMENT OF CHILDREN WITH ACUTE IMMUNE THROMBOCYTOPENIC PURPURA [J].

DEBRE, M ;

BONNET, MC ;

FRIDMAN, WH ;

CAROSELLA, E ;

PHILIPPE, N ;

REINERT, P ;

VILMER, E ;

KAPLAN, C ;

TEILLAUD, JL ;

GRISCELLI, C .

LANCET, 1993, 342 (8877) :945-949

[24] CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT-B OF PROTEIN-A FROM STAPHYLOCOCCUS-AUREUS AT 2.9-A AND 2.8-A RESOLUTION [J].

DEISENHOFER, J .

BIOCHEMISTRY, 1981, 20 (09) :2361-2370

[25] Convergent solutions to binding at a protein-protein interface [J].

DeLano, WL ;

Ultsch, MH ;

de Vos, AM ;

Wells, JA .

SCIENCE, 2000, 287 (5456) :1279-1283

[26] Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells [J].

Dhodapkar, KM ;

Kaufman, JL ;

Ehlers, M ;

Banerjee, DK ;

Bonvini, E ;

Koenig, S ;

Steinman, RM ;

Ravetch, JV ;

Dhodapkar, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) :2910-2915

[27] Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific kill T cells dentritic cells [J].

Dhodapkar, KM ;

Krasovsky, J ;

Williamson, B ;

Dhodapkar, MV .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (01) :125-133

[28] Inflammation in autoimmunity: receptors for IgG revisited [J].

Dijstelbloem, HM ;

van de Winkel, JGJ ;

Kallenberg, CGM .

TRENDS IN IMMUNOLOGY, 2001, 22 (09) :510-516

[29] Differential antigen processing by dendritic cell subsets in vivo [J].

Dudziak, Diana ;

Kamphorst, Alice O. ;

Heidkamp, Gordon F. ;

Buchholz, Veit R. ;

Trumpfheller, Christine ;

Yamazaki, Sayuri ;

Cheong, Cheolho ;

Liu, Kang ;

Lee, Han-Woong ;

Park, Chae Gyu ;

Steinman, Ralph M. ;

Nussenzweig, Michel C. .

SCIENCE, 2007, 315 (5808) :107-111

[30] The carbohydrate at FcγRIIIa Asn-162 -: an element required for high affinity binding to non-fucosylated IgG glycoforms [J].

Ferrara, C ;

Stuart, F ;

Sondermann, P ;

Brükner, P ;

Umaña, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) :5032-5036

← 1 2 3 4 5 6 7 8 9 10 →