Differential antigen processing by dendritic cell subsets in vivo

被引:1094
作者
Dudziak, Diana
Kamphorst, Alice O.
Heidkamp, Gordon F.
Buchholz, Veit R.
Trumpfheller, Christine
Yamazaki, Sayuri
Cheong, Cheolho
Liu, Kang
Lee, Han-Woong
Park, Chae Gyu
Steinman, Ralph M.
Nussenzweig, Michel C.
机构
[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA
[2] Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA
[3] Yonsei Univ, Coll Sci, Dept Biochem, Seoul 120749, South Korea
[4] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
关键词
D O I
10.1126/science.1136080
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8(+) DCs that express the cell surface protein CD205, CD8(-) DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
引用
收藏
页码:107 / 111
页数:5
相关论文
共 27 条
  • [1] Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells
    Allan, RS
    Smith, CM
    Belz, GT
    van Lint, AL
    Wakim, LM
    Heath, WR
    Carbone, FR
    [J]. SCIENCE, 2003, 301 (5641) : 1925 - 1928
  • [2] Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Bonifaz, L
    Bonnyay, D
    Mahnke, K
    Rivera, M
    Nussenzweig, MC
    Steinman, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) : 1627 - 1638
  • [3] Class II MHC peptide loading by the professionals
    Bryant, P
    Ploegh, H
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) : 96 - 102
  • [4] The nature of the MHC class I peptide loading complex
    Cresswell, P
    Bangia, N
    Dick, T
    Diedrich, G
    [J]. IMMUNOLOGICAL REVIEWS, 1999, 172 : 21 - 28
  • [5] Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody
    Dadaglio, G
    Nelson, CA
    Deck, MB
    Petzold, SJ
    Unanue, ER
    [J]. IMMUNITY, 1997, 6 (06) : 727 - 738
  • [6] Differential lysosomal proteolysis in antigen-presenting CeRs determines antigen fate
    Delamarre, L
    Pack, M
    Chang, H
    Mellman, I
    Trombetta, ES
    [J]. SCIENCE, 2005, 307 (5715) : 1630 - 1634
  • [7] Constitutive versus activation-dependent cross-presentation of immune complexes by CD8+ and CD8- dendritic cells in vivo
    den Haan, JMM
    Bevan, MJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (06) : 817 - 827
  • [8] CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo
    den Haan, JMM
    Lehar, SM
    Bevan, MJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) : 1685 - 1695
  • [9] MHC-DEPENDENT ANTIGEN-PROCESSING AND PEPTIDE PRESENTATION - PROVIDING LIGANDS FOR T-LYMPHOCYTE ACTIVATION
    GERMAIN, RN
    [J]. CELL, 1994, 76 (02) : 287 - 299
  • [10] A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells
    Guo, M
    Gong, SC
    Maric, S
    Misulovin, Z
    Pack, M
    Mahnke, K
    Nussenzweig, MC
    Steinman, RM
    [J]. HUMAN IMMUNOLOGY, 2000, 61 (08) : 729 - 738