Enantioselective preparation of 1,1-diarylethanes: Aldehydes as removable steering gronps for asymmetric synthesis

被引：106

作者：

Fessard, Thomas C. ^{[1
]}

Andrews, Stephen P. ^{[1
]}

Motoyoshi, Hajime ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 48期

关键词：

asymmetric synthesis; cleavage reactions; decarbonylation; diarylethanes; synthesis design;

D O I：

10.1002/anie.200702995

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cut it out! Convenient procedures have been delineated for the synthesis of optically active, functionalized 1,1-diaryl-ethanes by decarbonylation of β,β-diaryl-propionaldehydes. The process can be conducted as a one-pot 1,4-addition/decarbonylation sequence. Aldehydes are used as removable steering groups in this new strategy for the preparation of optically active building blocks. (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：9331 / 9334

页数：4

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