Catalytic enantioselective reduction of β,β-disubstituted vinyl phenyl Sulfones by using bisphosphine monoxide Ligands

被引：138

作者：

Desrosiers, Jean-Nicolas ^{[1
]}

Charette, Andre B. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3S 3J7, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 31期

关键词：

asymmetric catalysis; copper; phosphine ligands; reduction; sulfones;

D O I：

10.1002/anie.200701367

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Synthesis of chiral sulfones: A copper-phosphine complex efficiently provided optically active alkyl phenyl sulfones by hydrosilylation at room temperature. The reduction of β,β-disubstituted vinyl sulfones in the presence of the Me-DuPhos monoxide ligand lead to excellent enantiomeric excesses and high yields (see scheme). The prepared chiral sulfones were desulfonylated and subjected to Julia olefination conditions. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5955 / 5957

页数：3

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