Asymmetric, catalytic synthesis of α-chiral amines using a novel bis(phosphine) monoxide chiral ligand

被引:158
作者
Boezio, AA [1 ]
Pytkowicz, J [1 ]
Côté, A [1 ]
Charette, AB [1 ]
机构
[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada
关键词
D O I
10.1021/ja038291+
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have shown that Me-DuPHOS monoxide (BozPHOS) is a very effective ligand in the copper-catalyzed addition of dialkylzinc to N-phosphinoylimines providing access to α-chiral amines. The new ligand is particularly effective for the addition of the lesser reactive dimethylzinc. The major advantages of this process are high yields, broad substrate scope, and high enantioselectivities with low catalyst loading (3 mol %). Copyright © 2003 American Chemical Society.
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页码:14260 / 14261
页数:2
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