Catalytic enantioselective addition of dialkylzinc to N-diphenylphosphinoylimines.: A practical synthesis of α-chiral amines

被引：98

作者：

Boezio, AA ^{[1
]}

Charette, AB ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Stn Downtown, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 07期

关键词：

ASYMMETRIC CONJUGATE ADDITION; IMINES; DIETHYLZINC; REAGENTS; REACTIVITY; ORGANOZINC; ENONES; ZINC;

D O I：

10.1021/ja027673x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective addition of dialkylzinc reagents to N-diphenylphosphinoylimines derived from aryl-, furyl-, and cyclopropylaldehydes is efficiently catalyzed by a copper(II) triflate/(R,R)-MeDUPHOS complex. The yields are high (51-98%), and the enantiomeric excesses vary from 85 to 96%. This route provides a practical route to α-chiral amines. Copyright © 2003 American Chemical Society.

引用

页码：1692 / 1693

页数：2

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