Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a β-sulfonamide alcohol-titanium complex

被引：128

作者：

Xu, ZQ ^{[1
]}

Wang, R

Xu, JK

Da, CS

Yan, WJ

Chen, C

机构：

[1] Lanzhou Univ, Sch Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 46期

关键词：

addition; aldehydes; alkynes; asymmetric catalysis; sulfonamides;

D O I：

10.1002/anie.200352572

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three simple steps were required to prepare the β-sulfonamide alcohol ligand (L*) from L-phenylalanine. Its titanium complex efficiently catalyzes the asymmetric addition of phenylacetylene (2) to aromatic aldehydes 1 to form enantiomerically pure propargyl alcohols 3. Ts = p-toluenesulfonyl, R = substituted phenyl or naphthyl group.

引用

页码：5747 / 5749

页数：3

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