The synthesis of S 18986, a chiral AMPA receptor modulator, via catalytic asymmetric hydrogenation

被引：32

作者：

Cobley, CJ

Foucher, E

Lecouve, JP

Lennon, IC

Ramsden, JA

Thominot, G

机构：

[1] Dow Chem Co USA, Chirotech Technol Ltd, Dowpharma, Cambridge CB4 0WG, England

[2] Oril Ind, Bolbec, France

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 22期

关键词：

D O I：

10.1016/S0957-4166(03)00547-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric hydrogenation of a dihydropyrrolo-benzothiadiazine dioxide 1 with a diphosphine ruthenium diamine catalyst has been used to synthesize the AMPA receptor positive modulator tetrahydropyrrolo-benzothiadiazine dioxide 2 (S 18986) in high enantiomeric excess. The use of factorial experimental design led to significant improvements in the process parameters and improved enantioselectivity. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3431 / 3433

页数：3

共 18 条

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