Enantioselective hydrogenation of imines using a diverse library of ruthenium dichloride(diphospbine)(diamine) precatalysts

被引：181

作者：

Cobley, CJ ^{[1
]}

Henschke, JP ^{[1
]}

机构：

[1] Chirotech Technol Ltd, Cambridge CB4 0WG, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 1-2期

关键词：

asymmetric hydrogenation; DuPHOS; imine hydrogenation; ruthenium;

D O I：

10.1002/adsc.200390011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A range of aromatic and cyclic imines were subjected to asymmetric hydrogenation with catalysts derived from complexes of the type RuCl2(diphosphine)(diamine). Good to high enantioselectivities were observed. For each imine, a library of chiral complexes based on different diphosphine and diamine combinations was screened. A different combination of diphosphine and diamine was required each time to obtain the optimum enantioselectivity.

引用

页码：195 / 201

页数：7

共 36 条

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