A catalyst for efficient and highly enantioselective hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones

被引：190

作者：

Burk, MJ ^{[1
]}

Hems, W ^{[1
]}

Herzberg, D ^{[1
]}

Malan, C ^{[1
]}

Zanotti-Gerosa, A ^{[1
]}

机构：

[1] Chirotech Technol Ltd, Ascot Fine Chem, Cambridge CB4 0WG, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 26期

关键词：

D O I：

10.1021/ol000309n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] PhanePhos-ruthenium-diamine complexes catalyze the asymmetric hydrogenation of a wide range of aromatic, heteroaromatic, and alpha,beta -unsaturated ketones with high activity and excellent enantioselectivity.

引用

页码：4173 / 4176

页数：4

共 31 条

[1] EFFECTIVE ASYMMETRIC HYDROBORATION CATALYZED BY A RHODIUM COMPLEX OF 1-(2-DIPHENYLPHOSPHINO-1-NAPHTHYL)ISOQUINOLINE
BROWN, JM
HULMES, DI
LAYZELL, TP
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (22) : 1673 - 1674
[2] BRUNNER H, 1993, CATALYTIC ASYMMETRIC, pCH6
[3] Ru-BICP-catalyzed asymmetric hydrogenation of aromatic ketones
Cao, P
Zhang, XM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (06) : 2127 - 2129
[4] HIGHLY ENANTIOSELECTIVE BORANE REDUCTION OF KETONES CATALYZED BY CHIRAL OXAZABOROLIDINES - MECHANISM AND SYNTHETIC IMPLICATIONS
COREY, EJ
BAKSHI, RK
SHIBATA, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (18) : 5551 - 5553
[5] Doucet H, 1998, ANGEW CHEM INT EDIT, V37, P1703, DOI 10.1002/(SICI)1521-3773(19980703)37:12<1703::AID-ANIE1703>3.0.CO
[6] 2-I
[7] The first structural characterization of a [2.2]PHANEPHOS -: Transition-metal complex:: Structure of rac-[Pd(4,12-bis(diphenylphosphino)[2.2]paracyclophane)Cl2]
Dyer, PW
Dyson, PJ
James, SL
Martin, CM
Suman, P
[J]. ORGANOMETALLICS, 1998, 17 (20) : 4344 - 4346
[8] CATALYTIC ASYMMETRIC HYDROBORATION OF STYRENES
HAYASHI, T
MATSUMOTO, Y
ITO, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (09) : 3426 - 3428
[9] IKARIYA T, 1995, Patent No. 95308891
[10] ASYMMETRIC-SYNTHESIS USING CHIRALLY MODIFIED BOROHYDRIDES .3. ENANTIOSELECTIVE REDUCTION OF KETONES AND OXIME ETHERS WITH REAGENTS PREPARED FROM BORANE AND CHIRAL AMINO-ALCOHOLS
ITSUNO, S
NAKANO, M
MIYAZAKI, K
MASUDA, H
ITO, K
HIRAO, A
NAKAHAMA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (10): : 2039 - 2044

← 1 2 3 4 →