HIV subtypes induce distinct profiles of HIV-specific CD8+ T cell responses

被引：4

作者：

Baker, Chris A. R. ^{[1
]}

McEvers, Kimberly ^{[1
]}

Byaruhanga, Rose ^{[2
]}

Mulindwa, Rwabaingi ^{[2
]}

Atwine, Diana ^{[2
]}

Nantiba, Josephine ^{[2
]}

Jones, Norman G. ^{[1
]}

Ssewanyana, Isaac ^{[2
]}

Cao, Huyen ^{[1
]}

机构：

[1] Calif Dept Publ Hlth, VRDL, Richmond, CA 94804 USA

[2] Joint Clin Res Ctr, Kampala, Uganda

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2008年 / 24卷 / 02期

关键词：

D O I：

10.1089/aid.2007.0183

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells play an important role in controlling HIV infection and qualitative differences in HIV-specific CD8(+) responses may determine the degree of immune control. We studied 56 HIV-infected, ARV-naive Ugandans and examined the role of subtypes in modulating their HIV-specific T cell responses. Gag-specific responses were readily detectable in our study population. Interestingly, we found significantly decreased Gag-specific cytolysis (as measured by CD107 expression) in subtype D (n = 21) compared to subtype A (n = 35) HIV infection. Sequence analyses within identified epitopes suggest patterns of conservation that are subtype specific. We conclude that HIV subtypes may promote distinct profiles of T cells responses and immune control.

引用

页码：283 / 287

页数：5

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