Verbal memory impairment in subcortical ischemic vascular disease A descriptive analysis in CADASIL

被引：28

作者：

Epelbaum, S.

Benisty, S.

Reyes, S.

O'Sullivan, M. ^{[1
]}

Jouvent, E.

Duering, M. ^{[2
]}

Herve, D.

Opherk, C. ^{[2
]}

Hernandez, K.

Kurtz, A.

Viswanathan, A. ^{[3
,4
,5
]}

Bousser, M. G. ^{[6
]}

Dichgans, M. ^{[2
]}

Chabriat, H. ^{[6
]}

机构：

[1] Univ Cardiff, Wales Inst Cognit Neurosci, Cardiff, Wales

[2] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Clin Trials Unit, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] INSERM, U740, Fac Med Lariboisiere St Louis, Paris, France

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 12期

关键词：

CADASIL; Vascular dementia; Episodic memory; Cognitive test; MRI; MILD COGNITIVE IMPAIRMENT; NORMATIVE DATA; DEMENTIA; CRITERIA; INFARCTS; ATROPHY; STROKE; HIPPOCAMPAL; DIAGNOSIS; PATHOLOGY;

D O I：

10.1016/j.neurobiolaging.2009.12.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In the elderly, the high prevalence of Alzheimer's disease neuropathology presents a major challenge to the investigation of memory decline in common diseases such as small vessel disease. CADASIL represents a unique clinical model to determine the spectrum of memory impairment in subcortical ischemic vascular dementia (SIVD). One hundred and forty CADASIL patients underwent detailed clinical, neuropsychological and imaging analyses. The Free and Cued Selective Reminding Test was used as a measure of verbal memory. Forty-four out of 140 CADASIL patients (31.4%) presented with memory impairment according to this test. Eight out of 44(18.2%) subjects with memory impairment matched the definition of the amnestic syndrome of hippocampal type. While alterations in spontaneous recall were related to the severity of subcortical ischemic lesions, the profile of memory impairment, particularly the sensitivity to cueing was found related to other factors such as hippocampal atrophy. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：2172 / 2182

页数：11

共 63 条

[31] Neuropsychological profiles associated with subcortical white matter alterations and Parkinson's disease: Implications for the diagnosis of dementia [J].