Guatemalan plants extracts as virucides against HIV-1 infection

被引：12

作者：

Bedoya, Luis M. ^{[1
]}

Alvarez, Amparo ^{[1
]}

Bermejo, Mercedes ^{[1
]}

Gonzalez, Nuria ^{[1
]}

Beltran, Manuela ^{[1
]}

Sanchez-Palomino, Sonsoles ^{[1
]}

Cruz, Sully M.

Gaitan, Isabel

del Olmo, Esther ^{[2
]}

Escarcena, Ricardo ^{[2
]}

Garcia, Pablo A. ^{[2
]}

Caceres, Armando ^{[3
]}

Feliciano, Arturo San ^{[2
]}

Alcami, Jose ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Dept Inmunopatol SIDA, Madrid 28220, Spain

[2] Univ Salamanca, Fac Farm, CIETUS, Dept Quim Farmaceut, Salamanca 37007, Spain

[3] Lab Prod Fitofarmaceut Farmaya, Guatemala, Spain

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 6-7期

关键词：

HIV AIDS; microbicides; guatemalan plant extracts; recombinant virus;

D O I：

10.1016/j.phymed.2007.10.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Prevention methods to avoid transmission of pathogens, including HIV, are crucial in the control of infectious diseases, not only to block epidemic spread but to avoid long-term treatments leading to emergence of resistances and drug associated side effects. Together with vaccine development, the discovery of new virucidal agents represents a research priority in this setting. In the screening of new compounds with antiviral activity, three Guatemalan plant extracts from Justicia reptans, Neurolaena lobata and Pouteria viridis were evaluated with a classic antiviral assay and were found to inhibit HIV replication. This activity was corroborated by an original recombinant virus assay, leading us to perform a deeper study of the virucidal activity. Active fractions were non-toxic in vitro and also inhibited other enveloped viruses. Moreover, these fractions were able to inhibit the transfer of HIV from dendritic cells (DCs) to lymphocytes, that represents the main way of HIV spread in vivo. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：520 / 524

页数：5

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