A purine-like nickel(II) base pair for DNA

被引：129

作者：

Switzer, C ^{[1
]}

Sinha, S ^{[1
]}

Kim, PH ^{[1
]}

Heuberger, BD ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 10期

关键词：

DNA; metallo base pairs; molecular switches; nickel; nucleobases;

D O I：

10.1002/anie.200462047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal in the middle: A metallo base pair incorporating 6-pyridylpurine (Purp) was synthesized and characterized. Purp binds nickel (II) preferentially over other divalent ions and yields a base pair that is more stable than natural Watson-Crick pairs with high mismatch selectivity. Computational studies support a dimensional resemblance between Pur p·Ni2+·Purp (see structure) and natural base pairs. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1529 / 1532

页数：4

共 15 条

[1] Transition metal Ligands as novel DNA-base substitutes [J].

Brotschi, C ;

Leumann, CJ .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2003, 22 (5-8) :1195-1197

[2]

FRISCH MJ, 1998, GAUSSIAN98

[3] ZWITTERIONIC DNA [J].

HASHIMOTO, H ;

NELSON, MG ;

SWITZER, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (16) :7128-7134

[4] Cytostatic 6-arylpurine nucleosides III.: Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides [J].

Hocek, M ;

Holy, A ;

Votruba, I ;

Dvorákova, H .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2001, 66 (03) :483-499

[5] SYNTHESIS OF 2'-DEOXYTUBERCIDIN, 2'-DEOXYADENOSINE, AND RELATED 2'-DEOXYNUCLEOSIDES VIA A NOVEL DIRECT STEREOSPECIFIC SODIUM-SALT GLYCOSYLATION PROCEDURE [J].

KAZIMIERCZUK, Z ;

COTTAM, HB ;

REVANKAR, GR ;

ROBINS, RK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (21) :6379-6382

[6]

Lützen A, 2002, EUR J ORG CHEM, V2002, P2292

[7] Efforts toward expansion of the genetic alphabet: DNA polymerase recognition of a highly stable, self-fairing hydrophobic base [J].

McMinn, DL ;

Ogawa, AK ;

Wu, YQ ;

Liu, JQ ;

Schultz, PG ;

Romesberg, FE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (49) :11585-11586

[8] A novel copper-mediated DNA base pair [J].

Meggers, E ;

Holland, PL ;

Tolman, WB ;

Romesberg, FE ;

Schultz, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (43) :10714-10715

[9]

SCHWEITZER BA, 1995, J AM CHEM SOC, V117, P1863, DOI 10.1021/ja00112a001

[10] ENZYMATIC INCORPORATION OF A NEW BASE PAIR INTO DNA AND RNA [J].

SWITZER, C ;

MORONEY, SE ;

BENNER, SA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (21) :8322-8323

← 1 2 →