Cytostatic 6-arylpurine nucleosides III.: Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides

被引：122

作者：

Hocek, M ^{[1
]}

Holy, A

Votruba, I

Dvorákova, H

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CZ-16610 Prague 6, Czech Republic

[2] Inst Chem Technol, Lab NMR Spect, CZ-16628 Prague, Czech Republic

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2001年 / 66卷 / 03期

关键词：

purines; nucleosides; cross-coupling reactions; antineoplastic agents; antitumor activity; arylboronic acids; stannanes; organozinc reagents; Suzuki reaction;

D O I：

10.1135/cccc20010483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of fifteen 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides has been prepared by Pd-catalyzed cross-coupling reactions of 6-chloro-9-(2,3,5-tri-O-acetyl-beta -D-ribofuranosyl)-purine with arylboronic acids, hetarylzinc halides, hetarylstannanes or benzylzinc halides followed by deprotection. Structure-activity relationship study revealed that besides 6-(4-substituted phenyl)purine nucleosides, also some 6-hetaryl- and 6-benzylpurine ribonucleosides possess considerable cytostatic activity.

引用

页码：483 / 499

页数：17

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