9-benzylpurines with inhibitory activity against Mycobacterium tuberculosis

被引：133

作者：

Bakkestuen, AK ^{[1
]}

Gundersen, LL ^{[1
]}

Langli, G ^{[1
]}

Liu, FS ^{[1
]}

Nolsoe, JMJ ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00188-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl- tr arts-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1207 / 1210

页数：4

共 13 条

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