Convenient syntheses of 6-methylpurine and related nucleosides

被引：22

作者：

Hassan, AEA ^{[1
]}

Abou-Elkair, RAI ^{[1
]}

Montgomery, JA ^{[1
]}

Secrist, JA ^{[1
]}

机构：

[1] So Res Inst, Dept Organ Chem, Drug Discovery Div, Birmingham, AL 35255 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 07期

关键词：

D O I：

10.1080/15257770008035035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Efficient methods for the synthesis of 6-methylpurine (3), 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methylpurine (8), and 6-methyl-9-beta-D-ribofuranosylpurine (5) are described. Methodology involving the (Ph3P)(4)Pd catalyzed cross-coupling reaction of CH3ZnBr with several different 6-chloropurine derivatives is described in high yield. This methodology now provides a facile and high-yielding synthesis of 8, which is needed in significant amounts for studies in cancer gene therapy.

引用

页码：1123 / 1134

页数：12

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