Polarization of Tumor-Associated Macrophages: A Novel Strategy for Vascular Normalization and Antitumor Immunity

被引：80

作者：

Huang, Yuhui ^{[1
,2
]}

Snuderl, Matija ^{[1
,2
]}

Jain, Rakesh K. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Steele Lab Tumor Biol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

CANCER CELL | 2011年 / 19卷 / 01期

关键词：

OXYGENATION; THERAPY;

D O I：

10.1016/j.ccr.2011.01.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.

引用

页码：1 / 2

页数：2

共 10 条

[1] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis [J].

Andreu, Pauline ;

Johansson, Magnus ;

Affara, Nesrine I. ;

Pucci, Ferdinando ;

Tan, Tingting ;

Junankar, Simon ;

Korets, Lidiya ;

Lam, Julia ;

Tawfik, David ;

DeNardo, David G. ;

Naldini, Luigi ;

de Visser, Karin E. ;

De Palma, Michele ;

Coussens, Lisa M. .

CANCER CELL, 2010, 17 (02) :121-134

[2] Histidine-rich glycoprotein modulation of immune/autoimmune, vascular, and coagulation systems [J].

Blank, Miri ;

Shoenfeld, Yehuda .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2008, 34 (03) :307-312

[3] Anti-PIGF inhibits growth of VEGF(R)-Inhibitor-Resistant tumors without affecting healthy vessels [J].

Fischer, Christian ;

Jonckx, Bart ;

Mazzone, Massimiliano ;

Zacchigna, Serena ;

Loges, Sonja ;

Pattarini, Lucia ;

Chorianopoulos, Emmanuel ;

Liesenborghs, Laurens ;

Koch, Marta ;

De Mol, Maria ;

Autiero, Monica ;

Wyns, Sabine ;

Plaisance, Stephane ;

Moons, Lieve ;

van Rooijen, Nico ;

Giacca, Mauro ;

Stassen, Jean-Marie ;

Dewerchin, Mieke ;

Collen, Desire ;

Carmeliet, Peter .

CELL, 2007, 131 (03) :463-475

[4] Vascular normalization in Rgs5-deficient tumours promotes immune destruction [J].

Hamzah, Juliana ;

Jugold, Manfred ;

Kiessling, Fabian ;

Rigby, Paul ;

Manzur, Mitali ;

Marti, Hugo H. ;

Rabie, Tamer ;

Kaden, Sylvia ;

Groene, Hermann-Josef ;

Haemmerling, Guenter J. ;

Arnold, Bernd ;

Ganss, Ruth .

NATURE, 2008, 453 (7193) :410-U67

[5] Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy [J].

Jain, RK .

NATURE MEDICINE, 2001, 7 (09) :987-989

[6] Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy [J].

Jain, RK .

SCIENCE, 2005, 307 (5706) :58-62

[7] Macrophages, innate immunity and cancer: balance, tolerance, and diversity [J].

Mantovani, Alberto ;

Sica, Antonio .

CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (02) :231-237

[8] Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization [J].

Mazzone, Massimiliano ;

Dettori, Daniela ;

de Oliveira, Rodrigo Leite ;

Loges, Sonja ;

Schmidt, Thomas ;

Jonckx, Bart ;

Tian, Ya-Min ;

Lanahan, Anthony A. ;

Pollard, Patrick ;

de Almodovar, Carmen Ruiz ;

De Smet, Frederik ;

Vinckier, Stefan ;

Aragones, Julian ;

Debackere, Koen ;

Luttun, Aemout ;

Wyns, Sabine ;

Jordan, Benedicte ;

Pisacane, Alberto ;

Gallez, Bernard ;

Lampugnani, Maria Grazia ;

Dejana, Elisabetta ;

Simons, Michael ;

Ratcliffe, Peter ;

Maxwell, Patrick ;

Carmeliet, Peter .

CELL, 2009, 136 (05) :839-851

[9] HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF [J].

Rolny, Charlotte ;

Mazzone, Massimiliano ;

Tugues, Sonia ;

Laoui, Damya ;

Johansson, Irja ;

Coulon, Cathy ;

Squadrito, Mario Leonardo ;

Segura, Inmaculada ;

Li, Xiujuan ;

Knevels, Ellen ;

Costa, Sandra ;

Vinckier, Stefan ;

Dresselaer, Tom ;

Akerud, Peter ;

De Mol, Maria ;

Salomaki, Henriikka ;

Phillipson, Mia ;

Wyns, Sabine ;

Larsson, Erik ;

Buysschaert, Ian ;

Botling, Johan ;

Himmelreich, Uwe ;

Van Ginderachter, Jo A. ;

De Palma, Michele ;

Dewerchin, Mieke ;

Claesson-Welsh, Lena ;

Carmeliet, Peter .

CANCER CELL, 2011, 19 (01) :31-44

[10]

Winkler F, 2004, CANCER CELL, V6, P553, DOI 10.1016/j.ccr.2004.10.011

← 1 →