Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor-β

被引：22

作者：

Grässel, S

Tan, EML

Timpl, R

Chu, ML

机构：

[1] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

[3] Max Planck Inst, Dept Prot Chem, Martinsried, Germany

[4] Thomas Jefferson Univ, Dept Biochem & Mol Pharmacol, Philadelphia, PA 19107 USA

来源：

FEBS LETTERS | 1998年 / 436卷 / 02期

关键词：

transforming growth factor-beta; basic fibroblast growth factor; collagen XVI; arterial smooth muscle cell; dermal fibroblast;

D O I：

10.1016/S0014-5793(98)01122-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of bFGF and TGF-beta on the expression of type XVI collagen, a member of the fibril associated collagen family, in human dermal fibroblasts and arterial smooth muscle cells. We found that bFGF decreased the alpha 1(XVI) collagen mRNA to 18-24% of the controls, while TGF-beta increased the mRNA to 150-360%, Immunoprecipitation of metabolically labeled cells revealed corresponding, but less pronounced, changes at the protein levels. The results suggested that type XVI collagen expression is regulated by bFGF and TGF-beta in a manner similar to their regulation of the major type I fibrillar collagen produced bg these cells. (C) 1998 Federation of European Biochemical Societies.

引用

页码：197 / 201

页数：5

共 25 条

[1] Regulation of human interstitial collagenase (matrix metalloproteinase-1) promoter activity by fibroblast growth factor [J].