Affinity enhancement by multivalent lectin-carbohydrate interaction

被引:406
作者
Lee, RT [1 ]
Lee, YC [1 ]
机构
[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
关键词
glycoside cluster effect; multi-valent interaction; C-type lectins; affinity enhancement;
D O I
10.1023/A:1011070425430
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The binding of simple carbohydrate ligands by proteins often requires affinity enhancement to attain biologically relevant strength. This is especially true for endocytotic receptors and the molecules that engage in the first-line of defense. For such purposes, nature often utilizes a mode of affinity enhancement that arises from multiple interactions between the binding proteins and the carbohydrate ligands, which we term glycoside cluster effect. In this review article we give a number of examples and describe important factors in the multi-valent interactions that govern the degree of affinity enhancement.
引用
收藏
页码:543 / 551
页数:9
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